Essentials for Scientists in Academia and Industry

Historically, drug discovery is a lengthy, expensive, difficult, and inefficient process. But there is light at the end of the tunnel. We are inviting experts from academia and industry in order to elucidate the drug discovery process from basic research and target identification, including further characterization and development. For every step we provide state-of-the-art technology that can significantly improve your results.

Rescheduled to 2021!

Unfortunately, given the current epidemiological situation we decided to postpone the Seminar to next year. We will inform you as soon as we have fixed a new date!

Agilent Seahorse XF Technology – Measure what’s important to your cells

Using Agilent Seahorse XF Analyzers, scientists are continuing to obtain powerful functional data from live cells, in real time, gaining a greater understanding of cell metabolism. With this event we aim to provide an overview of the broad range of applications and to highlight the huge impact functional metabolism has.

Rescheduled to 2021!

Unfortunately, given the current epidemiological situation we decided to postpone the Seahorse Seminar and User Meeting to next year. We will inform you as soon as we have fixed a new date! 

In this webinar, Dr. Olaf Groß will discuss a link between metabolism and NLRP3 which has long been postulated and is supported by in vivo evidence and inhibitor data. Yet, the precise mechanisms of how NLRP3 senses metabolic disturbances and its relationship (if any) to NLRP3's ability to sense membrane damage remains highly controversial. Using new and established activators in combination with extracellular metabolic flux analysis and metabolomics, this research aims to unravel these connections.

Tune in to learn more about how: 

• Potassium efflux-independent NLRP3 activation by small molecules including anti-cancer drugs is highly sensitive to scavenging of reactive oxygen species
• Extracellular flux analysis reveals the ability of certain NLRP3 activators to inhibit the mitochondrial electron transport chain, leading to metabolic disturbance and growth arrest in cancer cells
• Small molecule screening reveals novel, potassium efflux-independent NLRP3 activators that do not disturb the ETC

Speaker:
Olaf Groß, PhD.
Professor of Experimental Neuropathology, Medical Center,
University of Freiburg, Germany

In this webinar, Stephen Chung, MD, of the University of Texas Southwestern Medical Center will discuss his team’s efforts to overcome this limitation by identifying cell surface markers present on clonal HSCs that will allow them to prospectively purify them for further functional and molecular studies. Towards this end, Mission Bio's Tapestri single-cell multi-omics platform has made possible the correlation of cell surface phenotype with genotype with unprecedented resolution and throughput.

Speaker:
Stephen Chung, MD
Assistant Professor
University of Texas Southwestern Medical Center

Genomics Live is Europe’s leading conference designed to deliver diagnostics and digital technologies into the clinic.