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Mission Bio

Tapestri® The Precision Genomics Platform

Targeted Single-Cell Solutions for High Impact Applications.

When you study or treat cancer, you don’t want to miss a single cell. Any cell that remains after treatment can lead to relapse. Mission Bio’s Tapestri® Platform is the only technology that provides single-cell targeted DNA sequencing at single-base resolution.

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Precise and Powerful

Tapestri sits on your bench top to scale single-cell DNA analysis as never before

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  • High throughput: Up to 10,000 cells
  • Detect rare subclones down to 0.1%
  • Resolve clonal architecture
  • Identify mutation co-occurrence
  • Small footprint of one square foot

Clonal Resolution with Single-Cell Precision

When you study or treat cancer, you don’t want to miss a single cell. Any cell that remains after treatment can lead to relapse. Mission Bio’s Tapestri ® Platform is the only technology that provides single-cell targeted DNA sequencing at single-base resolution.

Novel Droplet Microfluidics Power Our Platform

The Tapestri Instrument partitions thousands of cells into individual droplets, which act like mini reaction tubes enabling thousands of individual reactions simultaneously. Cell lysis and protease digestion then follow off-instrument enabling access to DNA for downstream amplification.

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Evolving subclonal mutations can resist and escape treatment

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The industry’s first scalable, customizable, single-cell DNA analysis platform.

The Mission Bio Tapestri Platform was developed to help advance precision medicine by enabling the accelerated and accessible detection of genomic variability within and across cell populations. Leveraging proprietary droplet microfluidics, the platform unlocks access to DNA at the single-cell level with a novel two-step protease workflow. This methodology provides flexibility for additional applications and customization capability.

Break Out of the Limitations of Bulk.

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The average read-out from conventional bulk sequencing misses the underlying genetic diversity across cell populations. To improve patient stratification, therapy selection, and disease monitoring we need insights into mutation co-occurrence within every single cell.

Single-Cell DNA Applications

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Hematology

Clonal evolution is foundational to disease progression in hematologic malignancies which can impact therapy response, resistance, relapse and residual disease. Tapestri Single-Cell DNA Panels have fixed content to address the most important hotspot SNVs and indels implicated in AML, MDS, MPN, CML, CMML, and JMML.

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Solid Tumor

Cellular heterogeneity in solid tumor cancers impacts clonal evolution and patient outcomes. Single-cell DNA solid tumor profiling enables high resolution of the genomic diversity in a variety of tumor types.

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Genome Editing

Advances in genome editing have transformed our ability to deliver precision therapies by engineering specific sequence edits in almost any cell in any genome. While powerful, these genome edits are not always accurate or efficient, and precision tools are needed to provide quality control in ensuring the appropriate edits have been incorporated. Tapestri Single-Cell Custom DNA Panels provides single-cell resolution to assess targeting efficiency of genome editing constructs.

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Tapestri Single-Cell DNA Panels

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The accurate and efficient single-cell detection of SNVs and indels across targeted gene panels is now possible with Tapestri Single-Cell DNA Panels.

Hematology

  • Tapestri Single-Cell DNA CLL Panel
  • Tapestri Single-Cell DNA
  • Tapestri Single-Cell DNA Myeloid Panel

Solid Tumor Profiling

  • Tapestri Single-Cell Tumor Hotspot Panel
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Tapestri Designer for Custom Single-Cell DNA Panels

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The only customizable single-cell targeted DNA solution that allows scientists to reveal the true clonal heterogeneity in research samples.

Focus your time and budget with targeted custom panels relevant to your research

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Testimonials

- Catherine Smith, MD, UCSF (Helen Diller Family Comprehensive Cancer Center)

"No technology prior to Tapestri has been able to give us the resolution to decipher co-occurring mutations in the same clones."

"These insights are especially important in our study of resistance mechanisms and combinatorial therapies in key clinical trials."

Koichi Takahashi, MD – The University of Texas (MD Anderson Cancer Center)

"This new capability of single-cell analysis is critical to better understanding precision therapy selection at diagnosis as well as disease monitoring and subsequent treatment strategy.”

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Mission Bio

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