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Nanoimager – The best super-resolution microscopy experience, on your desktop!

Super-Resolution in many forms

The Nanoimager offers various modes of operation including dSTORM, PALM, smFRET and supports illumination modes from epifluorescence to TIRF. With this range on offer, it's easier than ever to get the most out of fluorescence microscopy, both when imaging fixed samples stained with immunofluorescence protocols or during live-cell imaging.

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Imaging techniques and illumination modes

Super-Resolution in many forms

The Nanoimager offers various modes of operation including dSTORM, PALM, smFRET and supports illumination modes from epifluorescence to TIRF. With this range on offer, it's easier than ever to get the most out of fluorescence microscopy, both when imaging fixed samples stained with immunofluorescence protocols or during live-cell imaging.

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  • Single-Particle Tracking
    Microfluidics compatible
    Whole body heating
    • Dedicated tracking analysis
  • dSTORM & PALM
    • Resolution up to 20 nm
    • Real time rendering
    • 3D imaging
  • SIM & Confocal
    • Faster, easier super-resolution
    • Live and fixed samples
    • Wide selection of fluorophores
  • Single-Molecule FRET
    • Interactions within 1-10 nm range
    • Individual and group events
    • Dedicated smFRET analysis

Super-Resolution Microscopy Applications

The next generation of super-resolution microscope reveals biology in a new light. We can now image cells at the highest resolution, understand molecular interactions and dynamics and study the fundamentals of biology through single-molecule fluorescence.

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Extracellular Vesicles Hub

Extracellular vesicles (EVs) play key roles in cell-to-cell communication. EVs can cross biological barriers (such as the blood-brain barrier) and get internalized into the cell with a high degree of specificity.

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Pathogens Hub

Infectious diseases are caused by pathogenic microorganisms such as bacteria, viruses, fungi or prions. Super-resolution microscopy helps find more efficient ways of diagnosing, treating and preventing them.

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Other Case Studies

Biosafety Cabinets

Until recently, due to their size and design, the majority of super-resolution microscopes have not been able to support research in enclosed, ventilated biosafety cabinets. But things are changing.

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Tracking Extracellular Vesicles

Visualize and track EVs in solution or within cells to understand their behaviour.

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Tracking Viral Particles

Understanding and quantifying viral particle behavior.

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Viral Particle Imaging

Viral particles vary greatly in size, but are typically below the resolution limit of conventional light microscopy. Recently, super-resolution techniques have been employed to study their mechanistic and functional characteristics at a single-molecule level.

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Host Pathogen Interactions

By helping researchers to unravel new, dynamic information about virus particles, super-resolution micoscopy enables breakthroughs in the understanding of viral pathogens and in finding new targets to treat viral infection.

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Visualizing Extracellular Vesicles

Super-resolution imaging can be used to study fine morphological details and precise localization of EV-associated proteins.

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Tracking Single Molecules and Vesicles in cells

The Nanoimager can track single molecules and vesicles in both bacterial and eukaryotic cells with super-resolution microscopy.

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Quantitative Cellular Imaging

Gain detailed understanding of cellular features through multi-color super-resolution microscopy with advanced data analysis including colocalization and clustering.

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Protein Complex Assembly

Intensity measurements, super-resolution and multi-color labeling for characterizing protein complexes and their assembly.

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Molecular Mechanisms and Interactions

Using smFRET to understand molecular interactions and dynamics, including enzymes and substrates, protein aggregates in neurodegeneration and other protein-protein interactions.

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DNA Conformational Changes

A dynamic, real-time nanoscale ruler, now a general tool for characterizing molecular interactions and structure with Alternating Laser Excitation (ALEX) support.

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Epigenetic Mapping

Imaging specific target sites on DNA at the single-molecule level: a simple tool for characterizing the distribution of epigentic sites.

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DNA-PAINT shows sub-20nm resolution

DNA-PAINT provides easy localization-based super-resolution with nanorulers from GATTAquant GmbH.

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Nanoimager Features

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  • Microfluidics compatible
  • Temperature Control to 42℃
  • Drift Correction
  • Real-time Autofocus
  • High Laser Power Density
  • Unlimited Licences for Analysis Software
  • Class 1 Laser Product
  • LED Array for Brightfield Illumination
  • Piezo Stage with 2nm Step size

Videos

News & Events

On-Demand Webinar

ONI Webinar on

Harness the power of single-molecule detection, at your finger tips

Dr. Siobhan King presents a talk entitled, "Harness the power of single-molecule detection at your finger tips". She highlights applications that can be performed on the Nanoimager including detecting and visualizing extracellular vesicles as well as imaging and tracking viral particles.

ONI Webinar on

A journey through the cell: Unveiling life at a single-molecule level

Dr. Harmon presents a talk entitled, "A Journey through the Cell - Unveiling life at a single-molecule level". He highlights how to visualize structures from cell membrane to nucleus in unprecedented detail. With its small but mighty design, the Nanoimager delivers the ability to see, count and track single molecules from the convenience of your benchtop.

Resources

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