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S2 Genomics

Singulator Platform – Single Cells or Nuclei from Solid Tissues in Minutes

Solid Tissue Dissociation. Automated.
The bench-top Singulator System and its single-use cartridges enable reproducible, rapid and hands-off tissue dissociations into single-cell or nuclei suspensions. Its ability to perform cold dissociation minimizes the expression of stress-related genes in cells and helps preserve RNA quality in nuclei. Researchers can now easily obtain suspensions of nuclei or high-viability cells for a wide range of single-cell analyses including the isolation of nuclei from FFPE samples.

Now supporting:

  • FFPE Tissue Samples; Isolate nuclei from FFPE slices, enables snRNA-Seq for FFPE samples
  • Ultra-Low Volume Nuclei Isolations using just 500 μl of NIR, save on RNase inhibitor, great for sub-10 mg samples
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Say Goodbye To Manual Tissue Dissociation.

From tissue to single cells or nuclei in minutes with walk-away operation.

The Singulator™ enables rapid and hands-off tissue dissociations, making it easy for researchers to reproducibly prepare suspensions of nuclei or highly viable cells from small samples in high yield, for a wide range of single-cell  analyses.

The Singulator platform overcomes the challenges with manual tissue preparation methods by producing consistent cell or nuclei isolations from a variety of solid tissue samples, reducing hours of hands-on processing to minutes.

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Minimal Variability. Multiple Applications.

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Ideal for genomics, cell biology and other ‘omics applications, including scRNA-Seq, snRNA-Seq, ATAC-Seq, CITE-Seq, FACS, and immuno-oncology. S2 Genomics provides a selection of pre-set protocols and pre-formulated reagents for cell isolations for an expanding set of mouse, rat, and human tissues, including tumors. Isolate nuclei from fresh, flash frozen, OCT, and FFPE tissues.

Click below in order to see the wide range of tissues and organisms demonstrated on the Singulator Platform

Tissue Types

Nuclei in as Little as 7 Minutes

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Images of Nuclei Extracted From Flash Frozen Mouse Tissues

Reproducibly generate high-quality suspensions of nuclei from a wide range of tissues.

Merged DAPI-stained and bright-field images of small intestine, brain and heart tissue nuclei; DAPI stained liver nuclei.
(Courtesy of Dr. Minoda, Laboratory for Cellular Epigenomics, RIKEN Yokohama, Japan.)

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The Singulator Platform is Reproducible and Precise

The Singulator Platform isolates highly reproducible cell populations across technical replicates.

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Single Cells in 20-60 Minutes

Reproducibly generate suspensions of single cells in high yield with high-viability from a wide range of tissues.

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Performance At A Glance

The Singulator 100TM System comes with a unique Single-Shot MechanismTM for convenient cell-isolation reagent loading and a Reagent Chiller that stores reagents for up to 100 nuclei runs. 

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About the Technology

Sample to Genomics Solutions

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S2 Genomics is developing integrated sample preparation systems for processing tissues into genomic samples for single-cell genomics and cell biology studies.

The Singulator™ 100 enables rapid and hands-off tissue dissociations, making it easy for researchers to reproducibly prepare suspensions of nuclei or highly viable cells from small samples in high yield, for a wide range of single-cell  analyses.

The Singulator 100 overcomes the challenges with manual tissue preparation methods by producing consistent cell or nuclei isolations from a variety of solid tissue samples, reducing hours of hands-on processing to minutes.

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