header background-block header background-block header background-block header background-block

Find your product

Back to Products

S2 Genomics

Singulator Platform – Single Cells or Nuclei from Solid Tissues in Minutes

Solid Tissue Dissociation. Automated.
The bench-top Singulator System and its single-use cartridges enable reproducible, rapid and hands-off tissue dissociations into single-cell or nuclei suspensions. Its ability to perform cold dissociation minimizes the expression of stress-related genes in cells and helps preserve RNA quality in nuclei. Researchers can now easily obtain suspensions of nuclei or high-viability cells for a wide range of single-cell analyses including the isolation of nuclei from FFPE samples.

Now supporting:

  • FFPE Tissue Samples; Isolate nuclei from FFPE slices, enables snRNA-Seq for FFPE samples
  • Ultra-Low Volume Nuclei Isolations using just 500 μl of NIR, save on RNase inhibitor, great for sub-10 mg samples
filler image
filler image
filler image
filler image

Say Goodbye To Manual Tissue Dissociation.

From tissue to single cells or nuclei in minutes with walk-away operation.

The Singulator™ enables rapid and hands-off tissue dissociations, making it easy for researchers to reproducibly prepare suspensions of nuclei or highly viable cells from small samples in high yield, for a wide range of single-cell  analyses.

The Singulator platform overcomes the challenges with manual tissue preparation methods by producing consistent cell or nuclei isolations from a variety of solid tissue samples, reducing hours of hands-on processing to minutes.

filler image

Minimal Variability. Multiple Applications.

filler image

Ideal for genomics, cell biology and other ‘omics applications, including scRNA-Seq, snRNA-Seq, ATAC-Seq, CITE-Seq, FACS, and immuno-oncology. S2 Genomics provides a selection of pre-set protocols and pre-formulated reagents for cell isolations for an expanding set of mouse, rat, and human tissues, including tumors. Isolate nuclei from fresh, flash frozen, OCT, and FFPE tissues.

Click below in order to see the wide range of tissues and organisms demonstrated on the Singulator Platform

Tissue Types

Nuclei in as Little as 7 Minutes

filler image

Images of Nuclei Extracted From Flash Frozen Mouse Tissues

Reproducibly generate high-quality suspensions of nuclei from a wide range of tissues.

Merged DAPI-stained and bright-field images of small intestine, brain and heart tissue nuclei; DAPI stained liver nuclei.
(Courtesy of Dr. Minoda, Laboratory for Cellular Epigenomics, RIKEN Yokohama, Japan.)

filler image

The Singulator Platform is Reproducible and Precise

The Singulator Platform isolates highly reproducible cell populations across technical replicates.

filler image

Single Cells in 20-60 Minutes

Reproducibly generate suspensions of single cells in high yield with high-viability from a wide range of tissues.

filler image
filler image

Performance At A Glance

The Singulator 100TM System comes with a unique Single-Shot MechanismTM for convenient cell-isolation reagent loading and a Reagent Chiller that stores reagents for up to 100 nuclei runs. 

filler image

About the Technology

Sample to Genomics Solutions

filler image

S2 Genomics is developing integrated sample preparation systems for processing tissues into genomic samples for single-cell genomics and cell biology studies.

The Singulator™ 100 enables rapid and hands-off tissue dissociations, making it easy for researchers to reproducibly prepare suspensions of nuclei or highly viable cells from small samples in high yield, for a wide range of single-cell  analyses.

The Singulator 100 overcomes the challenges with manual tissue preparation methods by producing consistent cell or nuclei isolations from a variety of solid tissue samples, reducing hours of hands-on processing to minutes.

Videos

News & Events

Webinar

Resources

Supplier

S2 Genomics

Visit Suppliers Website

Request a demo or a quote

Measure mitochondrial respiration and glycolysis as well as ATP production rate of live cells.

Measure mitochondrial respiration, glycolysis, and ATP production in live cells in a 96-well format

Overview of Consumables for XF Analyzers

Simple, Automated, Charge-based DNA and RNA Extraction

LUNA-FX7™ Automated Fluorescence Cell Counter with unmatched cell counting accuracy

LUNA-III™ Automated Brightfield Cell Counter, designed to enhance your productivity and precision.

High multiplexing, high resolution in situ platform to combine single-cell and spatial genomics.

The best super-resolution microscopy experience, on your desktop.

NovoCyte Opteon Spectral Flow Cytometer Systems 3-5 Lasers and 73 detectors

The NovoCyte Penteon™ is a 5 laser benchtop flow cytometer with up to 30 colors

Pixel – Visualize live cell function at scale

Discover the World's First Two-Laser Image-guided Cell Sorter

Benchtop Microfluidic Cell Sorting with Two Lasers and up to Nine Colors

An incubator designed specifically for the cultivation of primary human cells

Seahorse XFe24 Analyzers measure OCR and ECAR of live cells in a 24-well plate format.

Automated high content image acquisition and analysis for drug discovery and cell biology

Multicolor fluorescence imaging to data analysis in one device

IsoLight – Automated Cellular Proteomics Hub

IsoLight and IsoSpark – Single-Cell Functional Proteomics Hub

The LUNA-FL™ can count in both brightfield and fluorescence mode

The LUNA-II™ automated cell counter gives you the ultimate brightfield cell counting experience.

The MARS® System is the “one-stop” modular solution for complete cell isolation from complex samples

The NovoCyte Quanteon™ is a 4 laser benchtop flow cytometer with up to 25 colors

The QUANTOM Tx Microbial Cell Counter automatically identifies and counts individual bacterial cells

Single Cells or Nuclei from Solid Tissues in Minutes

Tapestri® Platform: Untangle the complexity of cancer with true multi-omics.

Sterile, easy-to-use solutions for high cell integrity of single cell dispensing

Tissue Clearing System for electrophoretic tissue clearing

Optimized Microplate Solutions for Research & Drug Discovery

DeepLabel™ Antibody Staining Kit for Cleared Tissues

IsoPlexis Solutions and Kits

Autofocusing cell counting and declustering algorithm that counts individual yeast cells

Automated Fluorescence Cell Counter for Stem Cells & SVF

The NovoCyte Advanteon provides the flexibility of 1, 2, or 3 laser options.

Accurate & efficient single-cell detection of SNVs, indels, CNVs and LOH across targeted gene panels

Measure functional metabolism in 3 dimensions from in vitro spheroids

NovoCyte Consumables and Accessories for your Flow Cytometry needs.

Kits and reagents for real-time fluorescence plate reader-based live cell metabolism assays

Sterile, easy-to-use solutions for high cell integrity of single cell dispensing

The best value benchtop flow cytometer with high flexibility, enhanced sensitivity and resolution.

Optimized solution for assessing mitochondrial function.

Provides real-time measurements of glycolysis

Measures human (Hu) T cell activation response within several minutes of stimulation

Formulated media based on common culture media DMEM or RPMI, and optimized for use in XF assays.

Analytical method for measuring basal state mitochondrial fuel oxidation in live cells

Identification of drug-induced mitochondrial toxicity

Provides validated reagents to measure long chain fatty acid oxidation (FAO)

For in vitro studies of long chain fatty acid oxidation by intact cells.

Permeabilizes intact cells in culture, selectively targeting the cellular plasma membrane.

Seahorse XF Real-Time ATP Rate Assay

A suite of optimized solutions for rapidly measuring cellular substrate oxidation

Robust & accurate measurements of both glycolytic and mitochondrial activities in T cell populations

An Error occurred please try again later.
Please fill in all mandatory fields.

* All mandatory fields must be completed.

Thank you for contacting us!

{{ successMessage }}