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Vizgen, Inc.

MERSCOPE™ – A Complete Spatial Genomics Solution

Explore new dimensions with MERSCOPE™, the first high multiplexing, high resolution in situ platform to combine single-cell and spatial genomics analysis powered by MERFISH technology.

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Explore new dimensions through spatial context

MERSCOPE uses MERFISH technology to directly map and quantify the spatial distribution of hundreds to tens of thousands of RNA species in individual cells, without the need for downstream sequencing.

Vizgen integrated MERFISH technology with high resolution imaging, fluidics, image processing, and automation to deliver a complete end-to-end spatial genomics solution. The MERSCOPE Platform comes with everything your lab needs to get running. Vizgen built its expertise into every component of the system so you can easily obtain and analyze high quality MERFISH measurements.

  • Custom Gene Panel Design
  • Sample Preparation
  • Fluorescence Imaging
  • Data Visualization

Applications

MERFISH is a game-changing technology in single-cell genomics and has broad applications in both fundamental biology and medicine, ranging from basic science, to drug discovery, to clinical pathology. Given its ability to quantify RNAs across a wide range of abundances while preserving native context, MERFISH enables many applications of in situ transcriptomic analyses of individual cells in culture or complex tissues.

  • Oncology
  • Immunology
  • Neuroscience
  • Infectious Disease
  • Development Biology & Regenerative Medicine

Profile Large Tissue with Subcellular Resolution

Through combinatorial labeling, sequential imaging, and error-robust barcoding, MERFISH technology provides the highest detection efficiency and resolution available for spatially profiling the transcriptome, from whole tissue section to single-cell and finally sub-cellular imaging across the whole tissue. Vizgen is proud to offer a Data Release Program to provide researchers with public access to MERSCOPE-generated data.

Access Data Release
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MERSCOPE Features

  • High Sensitivity
    Detect low expressing genes that can be missed using other technologies.
  • High Spatial Resolution
    Localize RNA transcripts at a subcellular level with ≤100 nm resolution.
  • Multiplexing Power
    High multiplexing with custom gene panel design. Current chemistry up to 500 genes.
  • Versatility
    Measure your specified genes on many sample or tissue types.
  • Ease of Use
    Intuitive automation and complete reagent packs allow for a walk-away system.

MERSCOPE™ Vizualizer Software

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The MERSCOPE™ Vizualizer software enables users to interact, analyze, and interpret even the most complex datasets generated by a MERFISH experiment. Our intuitive software seamlessly combines spatial context at the single-cell level to assist researchers with gaining valuable biological insights. With the tool, you can easily visualize MERFISH data including:

  • Imaged cells
  • Detected transcripts
  • Heat map- 2D cells-genes table
  • Scatterplot-displays dimensionality reduced cells and cell clusters​
  • Generate high-resolution images

Testimonials

Hongkui Zeng, Ph.D. Executive Vice President and Director of the Allen Institute for Brain Science

"In the hands of the research community, I believe that MERSCOPE will be a powerful tool for standardizing the way we characterize different cell types..."

"In the hands of the research community, I believe that MERSCOPE will be a powerful tool for standardizing the way we characterize different cell types, not just in the brain, but also in the rest of the body, ultimately bringing a deeper level of understanding to all life science research."

Dr. Xianamin Xu, Ph.D. Professor University of California Irvine

"I'm excited to have a MERSCOPE system installed in our Center, where we will use it to explore the molecular mechanisms of Alzheimer's disease..."

"I'm excited to have a MERSCOPE system installed in our Center, where we will use it to explore the molecular mechanisms of Alzheimer's disease... I look forward to building on the proof-of-concept study, which identified where early changes in gene expression occur in a mouse model of Alzheimer's disease."

Multimedia

News & Events

News

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Bucher Biotec AG

New Representation: Vizgen, Inc.

MERSCOPE™ – A Complete Spatial Genomics Solution

Bucher Biotec is very proud to announce the exclusive distribution agreement with Vizgen for the Swiss market. Explore new dimensions with MERSCOPE™, the first high multiplexing, high resolution in situ platform to combine single-cell and spatial genomics analysis powered by MERFISH technology.

Vizgen is dedicated to pioneering the next generation of genomics, providing tools that demonstrate the possibilities of in situ single cell spatial genomics, setting the standard for the spatial genomics field. These tools are enabling researchers to gain new insight into the biological systems that govern human health and disease with spatial context.

Learn how Vizgen can accelerate your research

Resources

About MERFISH

Multiplexed Error-Robust Fluorescence in situ Hybridization

MERFISH is a massively multiplexed single-molecule imaging technology capable of simultaneously measuring the copy number and spatial distribution of hundreds to tens of thousands of RNA species in individual cells.

LEARN MORE ABOUT MERFISH
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