Xcell Biosciences Inc.
AVATAR System Family
AVATAR’s proprietary metabolic reprogramming technology delivers the most potent and persistent cells that are primed for clinical success.
AVATAR Technology
The Most Potent and Persistent Cell Therapies
- Proprietary incubation technology mimics in-vivo tumor microenvironments, replicating key stressors like hypoxia and pressure
- Optimized manufacturing conditions for CAR T, TIL, TCR T and Treg cells
Enhanced Cell Fitness, Even for Solid Tumors
- AVATAR-trained cells retain metabolic fitness and are better suited for tumor microenvironments
Process Development
AVATAR Odyssey
The AVATAR Odyssey lets you customize oxygen and pressure levels based on tumor type or native microenvironment, allowing cells to “train” for those specific conditions as they would in vivo. Doing so increases potency, persistence, and transduction.
- Identify optimal culture conditions in small scale, low cost workflows
- Fine-tune oxygen and hyperbaric pressure levels to seamlessly translate to manufacturing scale
- Rapidly screen cell therapy variables under physiologically relevant TME conditions to accelerate process development
Optimization
AVATAR AI
Predicting drug behavior in an immunosuppressive tumor microenvironment has never been easier. Avatar AI allows users to develop rapid & accurate potency assays for cell therapy products
- Real time, label free cell killing analysis designed to measure therapeutic performance within the immunosuppressive TME
- Utilize advanced machine learning algorithms to predict the efficacy of immunotherapies and cell therapies
- Develop rapid and accurate potency assays in physiologically relevant environments
Manufacturing
AVATAR Foundry
Cell therapy manufacturing re-imagined. An automated, closed system for the production of autologous cell therapies. The AVATAR Foundry is currently in beta
- Built to effortlessly scale your process from lab to clinic
- Enable rapid, low-cost manufacturing in a closed, automated bioreactor—ready for centralized or decentralized operations
- Adaptable to a range of volumes, supporting both short and long manufacturing workflows
Tackling the Barriers to Effective Cell Therapy
Cell Fitness in the Tumor Microenvironment
- Hypoxia, high interstitial pressure, and immunosuppressive proteins create a hostile microenvironment pH for therapeutic cells
- Conventional incubation systems fail to prepare cells for this reality—resulting in early exhaustion, poor in vivo performance, and limited clinical success
- Cell therapies produced in small-scale quantities face the problem of emulating those conditions in separate GMP manufacturing systems
Proven Performance Under Pressure
Explore how AVATAR technology enhances T cell potency, persistence, and efficiency by recreating the tumor microenvironment in manufacturing.
- Double the Killing Power of CAR T cells
- Persistent Killing Over Repeated Tumor Challenges
- 2X Enhanced Metabolism to Power T cell Potency
- 2X Increased Rapid Cell Expansion for Clinical-Scale
- 30% Increased Transduction and Lower Vector Cost
- Sustained Tumor Killing, Even at Low E:T Ratios
How It Works
AVATAR systems activate mechano- and oxygen-sensing pathways that improve:
- Glucose uptake and oxidative metabolism
- Stress resistance in hypoxic conditions
- Transduction vector access during pressurization
Cells become “TME-conditioned” and carry those traits into in vivo settings. The result? Cell therapy products that are better equipped to overcome immune suppression, persist longer, and deliver superior therapeutic outcomes compared to cells expanded under traditional conditions.
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Xcell Biosciences Inc.
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