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Portal Biotechnologies

Cell Engineering Simplified

High Throughout, Scalable Mechanoporation

Portal uses mechanical deformation to deliver virtually any cargo to diverse cell types while maintaining cell health. It has the potential for transformational impact across fi elds from drug discovery to bed -side cell therapies.

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Profile Multimedia News & Events Resources

Profile

Cell Engineering

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Portal Biotechnologies focuses on next-generation cell engineering and drug discovery technologies for both research and therapeutic applications. The company aims to enable precise genetic and molecular manipulation within living cells, making advanced cell-based therapies and drug screening more accessible and efficient.

Boost Cells with the Gateway System

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Research Scale Mechanical Delivery
 

Boost Cells Fast
Boost at over 10M cells/s

Buffer Flexibility
Compatible with many common media

Future Proof
Subscription includes free hardware upgrades to future models

High-Throughput Boosting with the Galaxy System

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Screen Multiple Cargoes At Once

High-throughput mechanical delivery

Cargo Flexibility
Screen small molecules, DELs, peptides and oligos

Easy Workflow Integration
Compatible with both manual workflows and liquid handlers

Cell and Buffer Flexibility
Compatible across cell lines, primary immune and stemcells

Booster™ Cartridge

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Delivery solutions available for T cells, B cells, NK cells, Monocytes, iPSCs and HSCs. Want another cell type? Just ask!

  • Proprietary Membrane
  • Optimized for delivery and cell viability
  • Compatible across cell concentration and buffers

Broad Compatibility

Portal’s platform supports delivery with a diverse matrix of cell types and cargoes.

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Intracellular Delivery is Critical to Many Research and Clinical Applications

Cell Engineering

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Gene Editing

Deletion, Correction, Integration

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Probing Intracellular Environment

Intracellular measurements, remote control, labelling, novel inhibitors

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Cell Therapies

Immunotherapies, gene correction, cell-based vaccines

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Regenerative Med

Engineered tissues, disease modeling, drug screening in patient cells

learn more about Cell Engineering Applications

Drug Discovery

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Hit Identification

Direct intracellular access for poorly permeable molecules

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Assay Reagent Delivery

Impermeable tagged probes, proteins, and antibodies

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Primary Cell Assays

Gene edit or modulate primary cells for assays

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Direct to Biology Assays

Intracellular delivery of DEL libraries

learn more about Drug Discovery Applications

Multimedia

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News & Events

News

Upcoming events

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Bucher Biotec Webinar on

Portal: Powering the Future of Cell Engineering and Drug Discovery

Join us for a focused webinar introducing Portal’s groundbreaking transfection technology – a universal platform that enables efficient, gentle, and reproducible intracellular delivery.

Portal is building the universal infrastructure for cell engineering and next generation drug discovery. Our proprietary mechanical system enables efficient delivery of RNA, gene editors, probes and other molecules into hard-to-transfect cells across a wide range of cell types and workflows. Just two years after founding, we’re already working with more than 100 customer sites, including the top 10 pharma. Researchers use Portal to interrogate disease biology through novel assays, improve hit prioritization and high-throughput screens, while also unlocking new classes of cell therapies. By providing a scalable and versatile way to engineer cells, Portal is becoming the essential platform for the next generation of drug discovery and point-of-care cell therapy innovation.

Portal’s growing product suite includes the Galaxy High-Throughput instrument, MilliBooster cartridges, and a DARPA-funded portable cell-engineering system launching in 2027. These offerings enable seamless scaling from R&D to point-of-care manufacturing. With a leadership team bringing decades of experience in clinical cell-therapy development and biotech operations, Portal is positioned to become the foundational backbone of cell engineering in both research and clinical settings.

Speaker:
Darby Kreienberg
Associate Scientist @ Portal Bio

  • 4. November 2025, 1:30 PM
Register

Resources

Supplier

Portal

Visit Suppliers Website

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INNO UV-Vis Absorbance Microplate Reader

LUNA-FB7™ Automated Brightfield Cell Counter with unmatched cell counting accuracy

LUNA-FX7™ Automated Fluorescence Cell Counter with unmatched cell counting accuracy

LUNA-III™ Automated Brightfield Cell Counter, designed to enhance your productivity and precision.

Luna-Gel™ – 3D Tissue Culture

Pixel – Visualize live cell function at scale

Platinum® Next-Generation Protein Sequencer™

Touch Imager – Lens-Free contact Western Blot imaging system with highest sensitivity and 100x range

Discover the World's First Two-Laser Image-guided Cell Sorter

Benchtop Microfluidic Cell Sorting with Two Lasers and up to Nine Colors

An incubator designed specifically for the cultivation of primary human cells

Automated high content image acquisition and analysis for drug discovery and cell biology

Multicolor fluorescence imaging to data analysis in one device

Next-Gen Cell Engineering

INNO-S Multimode Microplate Reader (Absorbance, Luminescence & Fluorescence)

IsoLight and IsoSpark – Single-Cell Functional Proteomics Hub

The LUNA-FL™ can count in both brightfield and fluorescence mode

The LUNA-II™ automated cell counter gives you the ultimate brightfield cell counting experience.

The MARS® System is the “one-stop” modular solution for complete cell isolation from complex samples

High multiplexing, high resolution in situ platform to combine single-cell and spatial genomics.

The QUANTOM Tx Microbial Cell Counter automatically identifies and counts individual bacterial cells

Single Cells or Nuclei from Solid Tissues in Minutes

Tapestri® Platform: Untangle the complexity of cancer with true multi-omics.

Sterile, easy-to-use solutions for high cell integrity of single cell dispensing

Tissue Clearing System for electrophoretic tissue clearing

DeepLabel™ Antibody Staining Kit for Cleared Tissues

INNO-H High-end Multimode Microplate Reader (Absorbance, Luminescence & Fluorescence)

Simple, Automated, Charge-based DNA and RNA Extraction

INNO UV-Vis Absorbance Microplate Reader

Autofocusing cell counting and declustering algorithm that counts individual yeast cells

Automated Fluorescence Cell Counter for Stem Cells & SVF

Accurate & efficient single-cell detection of SNVs, indels, CNVs and LOH across targeted gene panels

INNO-W96 Microplate Washer

Sterile, easy-to-use solutions for high cell integrity of single cell dispensing
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